Microbiological Pattern and Risk Factors of Bacterial
Colonization
in Patients with Clinically Stable Bronchiectasis
A. Khouri, M. Moubayed, W. Mjaouaz,
Pulmonary medicine Department, University
Hospital of Aleppo, Syria
Bronchiectasis: Chronic dilation of bronchi or bronchioles as a
sequel of inflammatory disease or obstruction often associated with
heavy sputum production.
The purpose of this study is to find microbiologic pattern & associated
risk factors in Syrian population and use more narrow spectrum antibiotics.
49 pts with proven diagnosis of bronchiectasis in a clinically
stable condition fulfilled the inclusion criteria.
Fiberoptic bronchoscopy was performed just after spirometry & BAL
sampling was achieved.
One of the major element in the pathogenesis of bronchiectasis
is the destructive effect of chronic airway infections, “the
vicious cycle” theory as coined by Cole
Cole PJ: A new look at the pathogenesis, management of persistent
bronchial sepsis: A ‘vicious circle’ hypothesis & its
logical therapeutic connotations. In Davies RJ (ed): Strategies for
the management of chronic bronchial sepsis. Oxford: Medicine Publishing
Foundation, 1984, pp 1-20.
more to read on the complete presentation to be seen on the University
website:
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Conclusions
1. The rate of colonization was higher than the other studies.
2- The dominant type of bronchiectasis was different (varicoid).
3- The number of patient with airflow limitation (FEV1<80%) was
different from those in Spain.
4- The predominant pathogen was different from those in Spain & Hong
Kong.
We may anticipate that future understanding and optimal management
of patients with chronic bronchiectasis will entail interventions
to modify or interfere with biofilms.
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