Asmanet ENFUMOSA : Summary report of the meeting by Pascal Chanez

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màj 23/07/98

ENFUMOSA
(courriel: Chanez (at) montp.inserm.fr )
The European Network For Understanding
Mechanisms of Severe Asthma
BIOMED 2 Program - European Commission

4th quaterly meeting, with the support of INSERM and
Merck Sharp & Dohme Laboratory
February 13-14th 1998 in Montpellier- France
(see programm, abstracts and experts comments )

Summary Report by Pascal Chanez

Asthma phenotyping/genotyping
Acute severe asthma
Pollution
Epithelium
Cytokines and chemokines
Airway smooth muscle
Markers of inflammation
Airway remodelling

Asthma phenotyping/genotyping

Severity definition clinical/epidemiological
Long term follow-up/variability
Exacerbation: definitions and causes
Difficult asthma/difficult asthmatic
Differences between the site of recruitment
Severe asthma related to steroid dependency (steroid myopathy)
Candidate genes
Linked to phenotypes (heterogeneous)
A priori severity classification
familial agregation for severity?
relevance to external factors
Increase the numbers of patients tested
need for repeatibility of the studies
genetic network for efficiency purposes

Abstrats: F-B. Michel, Ph Godard, B. Wallaert, T. Perez, F. Demenais, C. Pison

Session report: Ph. Tarodo, D. Jaffuel

Acute severe asthma
High mortality/High prevalence of smokers Education of patients and doctors Role for neutrophils /MMP-9 release role for proinflammatory cytokines specificity of therapeutical intervention	Abstracts: H. Yssel, M. Pretolani Session report: P. Jourdan

Pollution
Relation to indoor allergenic exposure Low doses exposure lead to BHR and eos activation (cells involved,dendritic?) Outdoor:experimental evidences Asthma exacerbations linked to OP Asthma prevalence:lack of proofs Diesel exhausts/cooperation with other factors	Abstracts: F. de Blay, M. Aubier Session report: A.M. Campbell

Epithelium
Asthma an epithelial disease relation between perception of symptoms and inflammation and shedding activation of epithelium via IgE receptors relation to in vivo conditions? fondamental abnormality early in the developement of disease?	Abstracts: A. Campbell, D. Dusser, D. Dusser Session report: I. Vachier

Cytokines and chemokines
Cytokines did not dicriminate between causes of asthma IL5 related to asthma severity and BHR CCR3 receptors crucial/regulation TH1/TH2 /gammadelta Tlc in asthma? role of animal models? factors involved in recruitment and survival mast cells GF regulation in vitro by steroids expression in asthma?	Abstracts : Ph. Gosset, M. Humbert, N. Frossart Session report: C. Abbal

Airway smooth muscle
IL-1ß increases SP induced HBR in vitro through a COX -2 mediated mechanism IL-1ß increases BK induced HBR in vitro IgE receptors within bronchial wall? Tryptase able to induce HBR to histamine relation to MC distribution? relation for a specific role for ASM as an inflammatory cell?	Abstracts: M. Molimard, J.M. Tunon de Lara Session report: S. Matecki

Markers of inflammation
Sputum simple standardized and safe neutrophils? glands, subepithelial layer? role of cough? Routine way Urine mediators EDN ? LTE4 In vivo vs in vitro cell mediators release is a total blood stimulation will be useful?	Abstratcs: P. Deviller, I. Vachier, I. Pin Session report: M. Romagnoli

Airway remodelling
Usual pattern of bronchial biopsies Release of MMP by Neutrophils MMP-9 fluid /AM sup increased in asthma Regulation by PKc mechanism TIMPs/MMP release inbalance role of BEC in asthma ? specificity to asthma? Macrophages or neutrophils ? site of remodeling ? lung biopsies?	Abstracts: C. Lafuma, G. Mautimo Session report: C. Abbal

Enfumosa

Congrès Conçue et réalisée par: Michel Godard (at)

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Date de création: 12 Février 1998 -Dernière mise à jour: 23/07/98Le secret des correspondances transmises sur le réseau Internet n'est pas garanti. Toute personne citée dispose d'un droit d'accès, de modification, de rectification et de suppression des données le concernant (art. 34 de laloi "Informatique et Libertés"n° 78-17 du 6 janvier 1978). Pour l'éxercer adressez-vous àMichel Godard (at)