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EAACI 1997 Summer Course Université d'été de Montpellier (Languedoc France) Course evaluation Provided by/avec le support de : Asthmology : from basic science to management Asthmologie : de la théorie à la pratique Saturday morning August 30, 1997                      Course title            (not including worksops)    Speaker   Course Objective QCM for course evaluation Course   slides From bench to bed Du laboratoire au malade Ph. Godard Yes Yes Yes 567Ko! Bronchial epithelial cells Cellules epitheliales A. Campbell W. Canonica Yes Yes   Eosinophils Eosinophiles P. Chanez Yes Yes Yes (179 K ppt) Mast cells and macrophages in inflammation Mastocytes et macrophages dans l'inflammation F. Laliberté   Yes   Thursday, August 28, 1997 Friday August 29, 1997 Saturday August 30, 1997 Monday September 1st, 1997 Tuesday September 2nd, 1997 Global course evaluation Return EAACI home page Return Asmanet...

EVALUATION AND FOLLOW-UP OF ASTHMA :
FROM BENCH TO BEDSIDE     Ph. Godard

Objective of the course :
1. Understand the importance of research laboratory for the management of bronchial asthma
2. Know the necessity of good clinical check-up for the evaluation and the follow-up of an asthmatic patient
3. Ask correctly the right complementary exams to perform.

Questions: 

1- Give an evaluation (from 1 to 10) to the following questions in order to appreciate airway obstruction :	Before   course	After course	Expert
a- shortness of breath (from the patient's point of view)	2	1	3	0
b- wheezing as assessed by the MD	0	3	3	0
c- measurement of PEFR	3	3	6	6
d- check PEFR during several days	9	8	8	3
e- assessment of FEV1	10	10	10	8

2- What is the best marker of airway inflammation ?	Before   course	After course	Expert
a- blood eosinophil count	13%	3%		3%
b- sputum eosinophil count	53%	49%		44%
c- clinical severity of asthma	40%	43%	c=yes	53%
d- exhaled NO concentration	0%	3%		3%
e- leukotriene concentration in the urine	17%	20%		6%

3- What is the best marker of airway remodelling ?	Before   course	After course	Expert
a- thickeness of basement membrane	53%	54%	a=yes	47%
b- hyaluronic acid concentration in BAL fluid	3%	14%		3%
c- FEV1 decline	25%	29%	c=yes	38%
d- clinical severity of asthma	9%	9%		6%
e- instability of PEFR	28%	26%		15%

BRONCHIAL EPITHELIAL CELLS   A. Campbell, W. Canonica

Objectives of the course :
1. To describe the morphology and function of bronchial epithelial cells.
2. To know how to sample bronchial epithelial cells in vivo and to study them in vitro.
3. To know the role of bronchial epithelial cells in bronchial asthma, which has been defined as a desquamative bronchitis.

Questions: 

1- What are the mediators which are released in vitro by bronchial epithelial cells ?	Before   course	After course	Expert
a- 15 HETE	73%	74%	a=yes	71%
b- histamine	6%	11%		14%
c- LTC4	30%	40%	c=yes	31%
d - Il-2	0%	11%		6%
e- ICAM-1	27%	66%	e=yes	51%

2- In order to study the bronchial epithelial cells in vitro what is the best sampling method ?	Before   course	After course	Expert
a- induced sputum	25%	3%		9%
b- broncho alveolar lavage	38%	14%		15%
c- bronchial biopsy	38%	54%	c=yes	38%
d- open lung biopsy	13%	11%		12%
e - bronchial brushing	9%	54%	e=yes	44%

3- Inhaled corticosteroid are able to repair bronchial epithelium. What is your knowledge ?	Before   course	After course	Expert
a- this is completly true	42%	37%		36%
b- this is completly false	6%	6%		3%
c- this is possible only if other treatments are used	29%	17%		21%
d- this possible only if the patient is allergic	3%	3%		0%
e- this is not known	29%	40%	e=yes	42%

EOSINOPHILS   P. Chanez

Objective of the course :
1. To know the fate of eosinophils from the bone-marrow to the tissues
2. To understand their potential role within the inflammed tissues.
3. To understand their putative involvment in airway diseases.
4. To know the impact at their level of different therapeutical intervention.

Questions: 

1- Bronchoalveolar lavage and sputum examinations have shown that certain cells are increased in the respiratory tract in asthma; what are these cells ?	Before   course	After course	Expert
A: eosinophils	30%	58%	A=yes	76%
B: neutrophils	36%	33%	B=yes	21%
C: basophils	3%	22%		6%
D: mast-cells	79%	94%		35%
E: lymphocytes	30%	31%		38%

2- What are the mediators the Eosinophils are able to release ?	Before   course	After course	Expert
A: Free oxygen radicals	97%	94%	A=yes	38%
B: LTB4	27%	33%		21%
C: TGF ß	21%	19%	C=yes	21%
D: ECP	42%	39%	D=yes	88%
E: Histamine	67%	61%		18%

3- What are the evidences implicating that esoinophils might mediate epithelial damage in asthma ?	Before   course	After course	Expert
A: Localisation above the epithelium layer	20%	44%	A=yes	31%
B: Cationic proteins are toxic in vitro to the epithelium	47%	61%	B=yes	58%
C: Cationic proteins are found within the epithelial layer	27%	39%	C=yes	36%
D: MBP is elevated in the blood of pregnant women	0%	3%		3%
E: Cationic protein levels are high in the sputum of asthmatics.	90%	94%	E=yes	69%

4- What are the evidences indicating that eosinophils are potentially related to the severity of asthma:	Before   course	After course	Expert
A: High number in corticodependent asthma	20%	4%		0%
B: Relationship between ECP level in the BAL and the clinical severity	60%	84%	B=yes	61%
C: Correlation between ECP in the BAL with the airflow impairment	40%	52%	C=yes	39%
D: Relationships between airway hyperresponsiveness and blood eosinophil levels	0%	12%		21%
E: Relationships between ECP level in the sputum and recent asthma exacerbation	60%	48%	E=yes	55%

INFLAMMATION   F. Laliberté

Questions: 

.EAACICongrès Conçue et réalisée par: Michel Godard (at) Top
Date de création: 1997- Dernière mise à jour: 23/07/98
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