3. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9236505&dopt=Abstract

[Medline] Park HS, Nahm DH.
Identification of IgE-binding components in occupational asthma caused by corn dust.
Ann Allergy Asthma Immunol. 1997 Jul;79(1):75-9. PMID: 9236505
Ann Allergy Asthma Immunol 1997 Jul;79(1):75-9 Related Articles, Links

Identification of IgE-binding components in occupational asthma caused by corn dust.

Park HS, Nahm DH.

Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea.

BACKGROUND: There have been some reports of corn dust-induced occupational asthma that suggest nonimmunologic mechanism. In this paper, we present a case of occupational asthma and rhinitis caused by corn dust where bronchoconstriction was induced by an IgE-mediated reaction. METHODS AND RESULTS: The patient had positive responses to weed and grass pollens as well as corn dust extracts. The bronchoprovocation test elicited an early asthmatic response to corn dust extracts. Serum-specific IgE and IgG4 antibodies to corn dust extracts were detected by enzyme-linked immunosorbent assay (ELISA). In order to identify further the allergenic component of the extracts, sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE) and electroblotting studies were performed. Ten IgE-binding components (9 to 140 kD) were detected within the corn dust extracts. CONCLUSION: These results suggest that inhalation of corn dust can cause IgE-mediated bronchoconstriction in an exposed worker.

PMID: 9236505 [PubMed - indexed for MEDLINE]